Role of gene promoter methylation regulated by TETs and DNMTs in the overexpression of HLA-G in MCF-7 cells.

In conclusion, the results indicated that overexpression of HLA-G in MCF-7 cells was induced by DNA methylation modification. The lower DNMT1 and DNMT3a and higher TET2 expression levels may be responsible for the abnormal DNA methylation of HLA-G in MCF-7. Treatment with TET inhibitor prevented aberrant HLA-G expression and DNA methylation in MCF-7. The present study may provide potential targets for novel anti-cancer drugs. PMID: 31086605 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research