Bile acid signaling in renal water regulation.

Bile acid signaling in renal water regulation. Am J Physiol Renal Physiol. 2019 May 15;: Authors: Li S, Li C, Wang W Abstract Emerging evidence has shown that bile acids play important roles in renal physiology and diseases by activating two major receptors, the nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled bile acid receptor-1 (Gpbar1, also known as TGR5). Both FXR and TGR5 have been identified in human and rodent kidneys, where they are profoundly involved in renal water handling. In mice, FXR- or TGR5-related gene deficiency has been associated with reduced aquaporin-2 (AQP2) expression accompanied with impaired urinary concentration ability. In this mini-review, we briefly discuss the current understanding of FXR/TGR5 signaling in the kidneys, with a special focus on the regulation of AQP2 expression by bile acids in the collecting ducts and its potential significance in disease conditions. PMID: 31091123 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research