Bone marrow-liver-thymus (BLT) immune humanized mice as a model to predict cytokine release syndrome.
This study demonstrates that BLT-humanized mice are capable of experiencing CRS, and could be used to screen biologics for this adverse event to enhance patient safety.
PMID: 31082370 [PubMed - as supplied by publisher]
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Yan H, Semple KM, Gonzaléz CM, Howard KE Tags: Transl Res Source Type: research
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