Report Provides Latest Incidence and Survival Statistics for Melanoma

The American Cancer Society's Cancer Facts&Figures 2019 report summarized the rate of melanoma over the past 30 years, mortality, and incidence based on sex and ethnicity.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news

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The global incidence of cancer is rapidly rising and remains a leading cause of death worldwide, highlighting the need for continued research focused on development of novel treatment strategies. According to the World Health Organization (WHO), about 8.8 million people die of cancer each year, with 600.000 new cancer cases expected in Brazil in 2018. This is partially due to the increased incidence of melanoma in recent years, which represents one of the fastest growing forms of cancer, with advanced metastatic forms carrying high mortality rates due to the development of drug resistance. Although early-stage melanoma can...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
This review focuses on what is the biological basis of esophageal cancer for immunotherapy, how to screen out the patients who can benefit from immunotherapy, and whether the toxic side effects of immunotherapy are manageable. AbstractConsidering the benefits of immunotherapy in advanced melanoma, non –small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma, we begin to consider whether immunotherapy is effective for esophageal cancer, which is extremely malignant and has a poor prognosis. There are a large number of clinical trials to study the applicatio n of immunotherapy suc...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: REVIEW Source Type: research
This study provides a unique transcriptomic resource for studying oral melanoma in dogs, and highlights lncRNAs that may potentially be diagnostic or therapeutic targets for human and veterinary medicine.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Authors: Malvi P, Wang B, Shah S, Gupta R Abstract Melanoma is the deadliest form of skin cancer. Despite recent advances in medicine and the development of new treatments for melanoma, cures remain elusive as acquired resistance to both targeted and immunotherapies are becoming common. Therefore, more studies are conducted to dissect underlying molecular mechanisms that drive melanoma growth in order to provide better therapeutic option. Here, employing a comprehensive and unbiased analysis of different RNA modification regulatory proteins using various publicly available databases we identify the most relevant RN...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Kuldkepp A, Karakai M, Toomsoo E, Reinsalu O, Kurg R Abstract Melanoma-associated antigen A (MAGEA) family proteins represent a class of tumor antigens that are expressed in a variety of malignant tumors, but their expression in normal tissues is restricted to germ cells. MAGEA family consists of eleven proteins that are highly conserved sharing the common MAGE homology domain (MHD). In the current study, we show that MAGEA4 and MAGEA10 proteins are incorporated into extracellular vesicles released by mouse fibroblast and human osteosarcoma U2OS cells and are expressed, at least partly, on the surface of r...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Publication date: Available online 22 June 2019Source: Seminars in Cancer BiologyAuthor(s): Fabrizio Fontana, Michela Raimondi, Alessandro Di Domizio, Roberta M. Moretti, Marina Montagnani Marelli, Patrizia LimontaAbstractMelanoma is the most fatal form of skin cancer. Current therapeutic approaches include surgical resection, chemotherapy, targeted therapy and immunotherapy. However, these treatment strategies are associated with development of drug resistance and severe side effects. In recent years, natural compounds have also been extensively studied for their anti-melanoma effects, including tumor growth inhibition, a...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionHealth professionals must consider this pathology when evaluating a burn scar or a chronic wound, performing a biopsy when suspicion is high. An early diagnosis, a prompt surgical intervention and a greater vigilance are the keys to success and survival.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
A cancer researcher at the University of Arkansas for Medical Sciences has received a five-year, $1.75 million grant from the National Cancer Institute to identify new tumor targets in the treatment of metastatic melanoma.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ01682A, PaperPavel Arsenyan, Jelena Vasiljeva, Ilona Domracheva, Iveta Kenepe-Lapsa, Anita Gulbe General aim of the current research is to find novel non-toxic small molecules with antimetastatic activity. Herein we present series of novel selenopheno[2,3-f]coumarins with low cytotoxic profile against cancer cells... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Development of resistance to inhibitors of BRAF (BRAFi) and MEK (MEKi) remains a great challenge for targeted therapy in patients with BRAF-mutant melanoma. Here, we explored the role of miRNAs in melanoma acq...
Source: Journal of Experimental and Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
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