Insight into microtubule nucleation from tubulin-capping proteins [Cell Biology]

Nucleation is one of the least understood steps of microtubule dynamics. It is a kinetically unfavorable process that is templated in the cell by the γ-tubulin ring complex or by preexisting microtubules; it also occurs in vitro from pure tubulin. Here we study the nucleation inhibition potency of natural or...

Source: Proceedings of the National Academy of Sciences - May 13, 2019 Category: Science Authors: Valerie Campanacci, Agathe Urvoas, Soraya Cantos–Fernandes, Magali Aumont–Nicaise, Ana–Andreea Arteni, Christophe Velours, Marie Valerio–Lepiniec, Birgit Dreier, Andreas Pluckthun, Antoine Pilon, Christian Pous, Philippe Minard, Be Tags: Biological Sciences Source Type: research