Plasma C-terminal agrin fragment and rapid kidney function decline in chronic kidney disease patients

This study addresses the value of tCAF as a predictor of rapid kidney function decline in CKD patients. We measured plasma tCAF in a retrospective observational cohort study of 277 prevalent CKD patients stage I-V. Using multivariable Cox proportional hazards regression analysis, we evaluated the association of tCAF with end-stage-renal-disease (ESRD), ≥30%-decline of estimated glomerular filtration rate (eGFR) and the composite endpoint of both, adjusting for eGFR, age, systolic blood pressure, proteinuria and diabetes. The median age was 58 [interquartile range 47, 71] years, 36% were female. Median tCAF level was 822 [594, 1232] pM, eGFR was 32 [19, 48] ml/min/1.73 m2. tCAF was correlated to eGFR and proteinuria (r = −0.76 and r = 0.49, P 
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research