Drug-response related genetic architecture of Bangladeshi population

Publication date: Available online 9 May 2019Source: Meta GeneAuthor(s): Tamim Ahsan, Abu Ashfaqur SajibAbstractMany Single Nucleotide Polymorphisms (SNPs) have been discovered to be responsible for inter-individual variability in drug response. Since allelic distribution and extent of linkage disequilibrium (LD) blocks of SNPs vary among populations, frequencies of different SNP alleles associated with drug response and patterns of LD should be analyzed separately for different populations. In the present study, we listed the SNPs associated with drug response along with the responsive drugs and calculated the frequencies of the major and minor alleles in the genomes of Bangladeshi individuals. We then analyzed the genotypic data to find LD blocks, tag SNPs (tSNP), frequencies of different haplotypes and association (crossover rates) between different LD blocks of the drug response related SNPs. Among 156 non-redundant autosomal drug response related SNPs, there are nineteen LD blocks and five tSNPs in Bangladeshi population. Certain minor SNP alleles in worldwide population are present as the major ones (with frequencies ≥0.5) in Bangladeshi population. Based on the available SNP data in the 1000 genome database, these particular SNP alleles have similar distributions in other South Asian populations (Telegu and Gujrati Indian, Punjabi Pakistani and Sri Lankan Tamil).
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research