Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis).

Relationships between Cytokine Levels and Disease Parameters during the Development of a Collagen-induced Arthritis Model in Cynomolgus Macaques (Macaca fascicularis). Comp Med. 2019 May 08;: Authors: Choi EW, Kim S Abstract In rheumatoid arthritis research, NHP models of collagen-induced arthritis are important because these species share manyimmunologic and pathologic features with humans. In addition, serum levels of various cytokines in patients with rheumatoidarthritis have been studied as immune markers for disease prediction, early diagnosis, and effective therapeutic management. The purpose of this study was to identify changes in cytokine levels that occur during the development of collagen-induced arthritis in female cynomolgus macaques (n = 8) and to assess the relationships between these changes and various disease parameters. Blood samples were collected weekly before (week 0) and after (weeks 1 through 7) immunization with typeII collagen; clinicopathologic and cytokine data from those samples and other clinical parameters were used in correlationanalysis. Serum levels of IFNγ, chemokine (C-C motif) ligand 2 (CCL2), and IL6 showed significant changes after generationof collagen-induced arthritis. IFNγ levels showed a strong negative correlation with body weight (an indicator of general body condition), and CCL2 and IL6 showed moderate negative correlation with body weight. Serum IL6 levels showed moderatepositive corr...
Source: Comparative Medicine - Category: Zoology Authors: Tags: Comp Med Source Type: research