Will Vertiflex Boost Boston Scientific 's Pain Portfolio?

Boston Scientific has slowed its M&A pace considerably this year compared to 2018, but that doesn't mean the company won't take advantage of tuck-in opportunities that come its way. Case in point, the company's pending $465 million cash acquisition of Vertiflex, announced on Wednesday. Carlsbad, CA-based Vertiflex is a private company that sells the Superion Indirect Decompression System, a device designed to improve physical function and reduce pain in patients with lumbar spinal stenosis (LSS). The procedure, which is primarily performed by doctors who treat chronic pain patients with therapies including spinal cord stimulation and radiofrequency ablation, is expected to hit $60 million in sales this year. FDA approved the device in 2015 for patients with moderate degenerative LSS. In addition to the $465 million upfront payment, Boston Scientific agreed to additional payments contingent on commercial milestones over the next three years. Mike Matson, a medtech analyst at Needham &Co., said in a note that it was a little surprising to see Boston Scientific enter the spinal surgery market, but he acknowledged that there probably are synergies with its existing pain business and he characterized the deal as a "typical" Boston Scientific transaction in which it acquires an asset that allows the company to go deeper within a disease state/disorder, in this case, chronic pain. "We believe the Superion System allows [Boston Scientific] to move up th...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Orthopedics Source Type: news

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Abstract Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrated macrophages, a key mediator of inflammation, in chronic neuropathic pain by LSS using an animal model. LSS was induced in adult male rats by cauda equina compression procedure using a silicone block within the epidural spaces of L5-L6 vertebrae. Locomotor deficit was observed after compress...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
Authors: Nishishinya Aquino MB, Pereda CA, Muñoz-Ortego J Abstract Rheumatic diseases involving the spine, mainly cervical and lumbar spine, are highly prevalent, and consume considerable health resources. Acupuncture is a medical procedure endorsed by the WHO, with a wide spectrum of medical applications. The aim of this study was to review the evidence on acupuncture efficacy in these diseases. A literature search was performed in MEDLINE, CENTRAL and EMBASE (May 2017): 535 citations. We included four global reviews(45 systematic reviews) and three Systematic Reviews(70 clinical trials). Acupuncture improv...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
g Liu The accurate segmentation of the paraspinal muscle in Magnetic Resonance (MR) images is a critical step in the automated analysis of lumbar diseases such as chronic low back pain, disc herniation and lumbar spinal stenosis. However, the automatic segmentation of multifidus and erector spinae has not yet been achieved due to three unusual challenges: (1) the muscle boundary is unclear; (2) the gray histogram distribution of the target overlaps with the background; (3) the intra- and inter-patient shape is variable. We propose to tackle the problem of the automatic segmentation of paravertebral muscles using a defo...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Condition:   Lumbar Spinal Stenosis Interventions:   Device: active tDCS;   Device: sham tDCS Sponsor:   Istanbul University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Tis the season for M&A in the orthopedics market. This time out Medtronic is acquiring Titan Spine for an undisclosed sum. Mequon, WI-based Titan Spine markets a full line of Endoskeleton interbody devices featuring its textured surface in the U.S., Europe, and Australia through its sales force and a network of independent distributors. Dublin-based Medtronic said interbody implants are spacers that can be inserted between the vertebrae during spinal fusion surgery to help relieve pressure on nerves and hold the vertebrae in place while fusion occurs. Implant material and shape is thought to play a role in the bone growth ...
Source: MDDI - Category: Medical Devices Authors: Tags: Orthopedics Source Type: news
Lumbar spinal stenosis (LSS) is a common and often debilitating condition in older people. It is characterized by neurogenic claudication, consisting of lower limb pain and neurological symptoms exacerbated by walking [1]. Patients with LSS often avoid walking because of neurogenic claudication, and have reduced walking distance and physical activity [2,3]. Inadequate physical activity is linked to the development of many chronic diseases such as cardiovascular diseases, type 2 diabetes, neurodegenerative diseases, and certain cancers [4].
Source: The Spine Journal - Category: Orthopaedics Authors: Tags: Clinical Study Source Type: research
The aim of this observational, cross-sectional study was to analyse lumbar magnetic resonance imaging (MRI) findings in patients with non-specific chronic low back pain (CLBP), and to evaluate any correlation with pain intensity and their capacity to predict neuropathic pain (NP) in these patients. Fifty-two patients with non-specific CLBP, between 21 and 62 years of age, 50% men, were investigated. Lumbar MRI was employed to assess disc degeneration, endplate changes, Modic changes, disc displacement, facet degeneration, foraminal stenosis and central lumbar spinal stenosis. The characteristics of pain were evaluated and...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Treating chronic low back pain (CLBP) with spine-focused interventions is common, potentially dangerous, and often ineffective. We posit that CLBP in older adults is a geriatric syndrome – a final common pathway for the expression of multiple contributors. We have published evidence and expert consensus-based algorithms to guide evaluation and treatment of key biopsychosocial CLBP contributors in older adults – hip osteoarthritis, myofascial pain, fibromyalgia, sacroiliac joint syndrome, lumbar spinal stenosis, leg length inequality, lateral hip/thigh pain, anxiety, depression, insomnia, and maladaptive coping....
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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