Will Vertiflex Boost Boston Scientific 's Pain Portfolio?

Boston Scientific has slowed its M&A pace considerably this year compared to 2018, but that doesn't mean the company won't take advantage of tuck-in opportunities that come its way. Case in point, the company's pending $465 million cash acquisition of Vertiflex, announced on Wednesday. Carlsbad, CA-based Vertiflex is a private company that sells the Superion Indirect Decompression System, a device designed to improve physical function and reduce pain in patients with lumbar spinal stenosis (LSS). The procedure, which is primarily performed by doctors who treat chronic pain patients with therapies including spinal cord stimulation and radiofrequency ablation, is expected to hit $60 million in sales this year. FDA approved the device in 2015 for patients with moderate degenerative LSS. In addition to the $465 million upfront payment, Boston Scientific agreed to additional payments contingent on commercial milestones over the next three years. Mike Matson, a medtech analyst at Needham &Co., said in a note that it was a little surprising to see Boston Scientific enter the spinal surgery market, but he acknowledged that there probably are synergies with its existing pain business and he characterized the deal as a "typical" Boston Scientific transaction in which it acquires an asset that allows the company to go deeper within a disease state/disorder, in this case, chronic pain. "We believe the Superion System allows [Boston Scientific] to move up th...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Orthopedics Source Type: news

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Conclusion] The results of this study suggest that manual manipulation therapy is an effective intervention for treating pain and dysfunction in patients with lumbar spinal stenosis. PMID: 32884169 [PubMed]
Source: Physical Therapy - Category: Physiotherapy Authors: Tags: J Phys Ther Sci Source Type: research
Conclusion. Patients on chronic opioids prior to spine surgery are more likely to have a longer hospital stay and continue on opioids for a longer time after surgery, compared with patients not on chronic opioid therapy. Spine surgeons and pain specialists should seek to identify patients on chronic opioids before surgery and evaluate strategies to optimize pain management in the pre- and postoperative course. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: CLINICAL CASE SERIES Source Type: research
Conclusion5R-STS performance differs according to the etiology of back and leg pain, even after adjustment for demographic covariates. In combination with machine learning algorithms, OFI can be used to infer the etiology of spinal back and leg pain with accuracy comparable to other diagnostic tests used in clinical examination.Graphic abstractThese slides can be retrieved under Electronic Supplementary Material.
Source: European Spine Journal - Category: Orthopaedics Source Type: research
CONCLUSIONS: Although MRI is crucial for evaluating lumbar spinal stenosis, it cannot replace but is rather complementary to a good patient history and clinical examination or the results of local diagnostic injections. PMID: 31743983 [PubMed - as supplied by publisher]
Source: Journal of Back and Musculoskeletal Rehabilitation - Category: Orthopaedics Tags: J Back Musculoskelet Rehabil Source Type: research
Low back pain, radicular leg pain, and lumbar spinal stenosis are the most common of all chronic pain disorders. Discogenic pain is related to distress of annular fibers and tears, whereas spinal stenosis is related to reduction of the spinal canal dimensions and compression of the neural elements; radicular pain is mainly related to disc herniation and is initially managed conservatively. The percutaneous minimally invasive approach in discogenic and radicular pain is designed to reduce the volume of the nucleus pulposus in patients with failure of medical and physical treatment prolonged for at least 6 weeks.
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
Abstract Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrated macrophages, a key mediator of inflammation, in chronic neuropathic pain by LSS using an animal model. LSS was induced in adult male rats by cauda equina compression procedure using a silicone block within the epidural spaces of L5-L6 vertebrae. Locomotor deficit was observed after compress...
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Tags: Int Immunopharmacol Source Type: research
Authors: Nishishinya Aquino MB, Pereda CA, Muñoz-Ortego J Abstract Rheumatic diseases involving the spine, mainly cervical and lumbar spine, are highly prevalent, and consume considerable health resources. Acupuncture is a medical procedure endorsed by the WHO, with a wide spectrum of medical applications. The aim of this study was to review the evidence on acupuncture efficacy in these diseases. A literature search was performed in MEDLINE, CENTRAL and EMBASE (May 2017): 535 citations. We included four global reviews(45 systematic reviews) and three Systematic Reviews(70 clinical trials). Acupuncture improv...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
g Liu The accurate segmentation of the paraspinal muscle in Magnetic Resonance (MR) images is a critical step in the automated analysis of lumbar diseases such as chronic low back pain, disc herniation and lumbar spinal stenosis. However, the automatic segmentation of multifidus and erector spinae has not yet been achieved due to three unusual challenges: (1) the muscle boundary is unclear; (2) the gray histogram distribution of the target overlaps with the background; (3) the intra- and inter-patient shape is variable. We propose to tackle the problem of the automatic segmentation of paravertebral muscles using a defo...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Condition:   Lumbar Spinal Stenosis Interventions:   Device: active tDCS;   Device: sham tDCS Sponsor:   Istanbul University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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