Systematic review and meta-analysis of statin therapy and outcome after ischaemic stroke

Source: Stroke Area: News Data are conflicting regarding the relationship between acute statin therapy and outcome after ischaemic stroke. Some authors have reported improved survival and functional outcome associated with statin treatment, but these findings have not been consistently replicated. Some authors have also reported worse outcomes in patients treated with the combination of acute statins and IV thrombolysis, though these results have not been consistently reproduced. Large randomised trials of acute statin therapy after stroke may resolve these issues, but are expensive and require several years to conduct. Meta-analyses of existing observational studies and randomised trials may help to clarify the conflicting results of available data and better inform the rationale and design of large clinical trials.   Researchers hypothesised that statin treatment at the time of ischaemic stroke onset would be associated with greater survival and improved functional outcome at early and late ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news