Therapeutic potential of andrographolide-loaded nanoparticles on a murine asthma model

In conclusion, AGNP effectively controlled mild and severe asthma and the pulmonary administration of AGNP was more efficacious than the oral route.Graphical AbstractAndrographolide loaded nanoparticles successfully suppressed inflammatory mediators associated with ovalbumin induced asthma in mice, where the efficacy of nanoparticle was found to be better in pulmonary administration than its oral administration. The formulation showed improved bioavailability than the free drug. Different pharmacokinetic parameters and biodistribution of andrographolide in plasma and lung was determined by LC–MS/MS and radiolabeling study. Such formulation of relatively low toxic and sparingly water soluble natural agent like andrographolide can be useful clinically in controlling both severe and mild asthma.
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research