A Single Dose of 225Ac-RPS-074 Induces a Complete Tumor Response in an LNCaP Xenograft Model
Conclusion: A single dose of 148 kBq of 225Ac-RPS-074 induced a complete response in 86% of tumors, with tumor–to–normal-tissue ratios that predict an improved therapeutic index. The use of the macropa chelator enabled quantitative radiolabeling and may facilitate the clinical translation of this promising targeted α-therapeutic.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Kelly, J. M., Amor-Coarasa, A., Ponnala, S., Nikolopoulou, A., Williams, C., Thiele, N. A., Schlyer, D., Wilson, J. J., DiMagno, S. G., Babich, J. W. Tags: Basic Source Type: research
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