Glycolic acid Attenuates UVB-induced Aquaporin-3, Matrix Metalloproteinase-9 Expression, and Collagen Degradation in Keratinocytes and Mouse Skin.

Glycolic acid Attenuates UVB-induced Aquaporin-3, Matrix Metalloproteinase-9 Expression, and Collagen Degradation in Keratinocytes and Mouse Skin. Biochem J. 2019 Apr 29;: Authors: Tang SC, Tang LC, Liu CH, Liao PY, Lai JC, Yang JH Abstract Ultraviolet-B exposure causes an inflammatory response, photoaged-skin, and degradation of extracellular matrix proteins including collagen and elastin. The regulation of these genes was suggested as an important mechanism to attenuate skin aging. Glycolic acid (GA) is commonly present in fruits and recently used to treat dermatological diseases. We had reported that GA slows down cell inflammation and aging caused by UVB. Little is known about GA retard the skin premature senescence or how to impede these events. To investigate the potential of GA to regulate the expression of MMPs and collagen, GA was topically applied onto human keratinocytes and the C57BL/6J mice dorsal skin. In the present study, we demonstrated that GA reduced UVB-induced type-I procollagen expression and secretory collagen levels. GA reverted and dose-dependently increased the levels aquaporin-3 (AQP3), the expression of which was down-regulated by UVB. The UV-induced MMP-9 level and activity were reduced by GA pre-treatment. Concomitantly, GA reverted mitogen-activated protein kinase (MMP-9) activation and inhibited the extracellular signal-regulated kinase activation (p38, pERK) triggered by UVB. The animal model also pre...
Source: The Biochemical Journal - Category: Biochemistry Authors: Tags: Biochem J Source Type: research