Formation of a Toxic Quinoneimine Metabolite from Diclofenac: A Quantum Chemical Study

Conclusion: The results demonstrate the possibility of formation of quinoneimine metabolite due to various factors that are involved in the metabolism of diclofenac. The present study may provide the structural in-sights during the drug development processes to avoid the metabolism directed idiosyncratic toxicity.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research