Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinomas

This study analyzes the role of insulin-like growth factor (IGF) signaling in adrenocortical carcinoma. Our results demonstrate that IGF1 overexpression caused, in part, by gene copy amplification, is associated with non-functional, early stage tumors as well as aberrant expression of the metastasis promoting gene SL12AC7.

Source: Journal of the American College of Surgeons - April 25, 2019 Category: Surgery Authors: Taylor C. Brown, Norman G. Nicolson, Adam Stenman, C Christofer Juhlin, Courtney E. Gibson, Glenda G. Callender, Reju Korah, Tobias Carling Tags: New England Surgical Society Article Source Type: research