Surgical outcomes of cavovarus foot deformity in children with Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease (CMT) is a heterogeneous group of inherited peripheral neuropathies affecting 3 to 82 per 100,000 individuals of both sexes and all backgrounds [1]. CMT is characterised by demyelination and/or axonal degeneration of the peripheral nerves, with typical onset in the first two decades of life [2,3]. More than 90 causative genes have been identified so far, and CMT type 1A is the most common subtype [4]. Most patients exhibit a length-dependent progression of symptoms and impairments, with symptoms initially distal at the feet and hands, progressing proximally.

Source: Neuromuscular Disorders - April 25, 2019 Category: Neurology Authors: Ting Lin, Paul Gibbons, Anita J. Mudge, Kayla M.D. Cornett, Manoj P. Menezes, Joshua Burns Source Type: research