Comorbidities and the impact of atopic dermatitis
Atopic dermatitis (AD) is a common, chronic inflammatory skin disease that affects children and adults. Several international studies examined the incidence of AD and found a broad range across different countries and periods of observation (from 2,150 per 100,000 person-years in Denmark 1997-20111 to 17,600 per 100,000 person-years in Germany 19972. While no studies examined the incidence of AD in the United States (US), several studies explored AD prevalence. The US prevalence of AD was 12% (2012 National Health Interview Survey [NHIS]) to 13% (2007-2008 National Survey of Children ’s Health [NSCH]) in children (age
This study sought to identify AD endotypes based on allergen sensitization, S. aureus reactivity, and inflammatory signature. The study included 76 adults with moderate to severe AD and 39 healthy controls. All underwent serologic assessment of total IgE and allergen-specific antibodies to a wide range of environmental and food allergens, as well as antibodies against S.
Biologics have revolutionized medical therapy in the past 2 decades. Allergic Diseases have benefited from this revolution as a variety of biologics have impacted all categories of allergic diseases. Anticytokines directed at type 2 immunity has helped in the treatment of all allergic conditions covered in this issue ranging from Allergic Rhinitis to Asthma to Atopic Dermatitis to Food Allergy and others. Obviously, the ravages of COVID-19 on processes involved in biologic treatment are a consideration, but current thinking suggests such therapies should not be affected by the pandemic.
CONCLUSION: Atopic disorders, previously recognized as predictors of poor sleep, are associated with COPCs after accounting for sleep problems. PMID: 32975542 [PubMed - as supplied by publisher]
CONCLUSIONS: Our study suggests that in BPS patients' families, fibromyalgia and autoimmune diseases including asthma, and especially the non-allergic form of asthma, may be over-represented. PMID: 32964777 [PubMed - as supplied by publisher]
CONCLUSION: Higher PM2.5 during the first trimester of pregnancy and low CB vitamin D affected early onset persistent AD, and the most sensitive window was weeks 6-7 of gestation. Placental DNA methylation mediated this effect. PMID: 32971247 [PubMed - as supplied by publisher]
The effects of prenatal PM2.5 and vitamin D on the atopic dermatitis (AD) phenotypes have not been evaluated. DNA methylation and cord blood (CB) vitamin D could represent a plausible link between prenatal PM2.5 exposure and offspring ’s AD.
Authors: Seok SH, An JH, Shin JU, Lee HJ, Kim DH, Yoon MS, Kim HJ PMID: 32935496 [PubMed]
CONCLUSION: IL-22 was associated with type 2 inflammatory reactions in NP. The IL-22/IL-22Ra1 axis was enhanced and might be involved in type 2 inflammatory reactions via TSLP production in NP. PMID: 32935490 [PubMed]
Authors: Nahm DH, Ye YM, Shin YS, Park HS, Kim ME, Kwon B, Cho SM, Han J Abstract PURPOSE: The management of patients with atopic dermatitis (AD) is often difficult. We hypothesized that repeated intramuscular administration of autologous total immunoglobulin G (IgG) could induce clinical improvement in patients with AD through immune modulation. This clinical trial was conducted to evaluate the efficacy, safety, and immunomodulatory effect of the intramuscular administration of autologous total IgG in patients with AD. METHODS: In this randomized, double-blind, placebo-controlled trial, 51 adolescent and adult...
Authors: Kim SM, Park CO PMID: 32935484 [PubMed]