The histone demethylase Kdm4 suppresses activation of hepatic stellate cell by inducing MiR-29 transcription.
In conclusion, our data delineate a novel epigenetic mechanism underlying HSC activation. Targeting this axis may yield potential therapeutics against liver fibrosis.
PMID: 31014673 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Kong M, Wu J, Fan Z, Chen B, Wu T, Xu Y Tags: Biochem Biophys Res Commun Source Type: research