Does the Akt pathway play a role in follicle activation after grafting of human ovarian tissue?

ConclusionsThis study confirms that primordial follicle activation is an early event after transplantation, and significant follicle death also contributes to the burnout effect, eventually resulting in early depletion of the ovarian reserve. Increased Akt phosphorylation on day 3 post-grafting suggests it plays a role in follicle activation and subsequent burnout.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research