Compromised global embryonic transcriptome associated with advanced maternal age

ConclusionsA significant, overall decreased global transcriptome was observed in blastocysts from AMA women. The ESR1/SP1/CREBBP pathway, in particular, was found to be a highly significant upstream regulator impacting biological processes that are vital during embryonic patterning and pre-implantation development. These results provide evidence that AMA embryos are compromised on a cell signaling level which can repress the embryo ’s ability to proliferate and implant, contributing to a deterioration of reproductive outcomes.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research