Selective vulnerability in α-synucleinopathies

In conclusion, we think that it is the confluence of this disruption of the cellular metabolic state and α-syn structural equilibrium through the anatomical connectivity which appears to initiate cascades of pathological processes triggered by genetic, environmental, or stochastic events that result in the “death by a thousand cuts” profile of α-synucleinopath ies.
Source: Acta Neuropathologica - Category: Neurology Source Type: research