114 Cutaneous T-Cell lymphoma is genetically and clonotypically heterogeneous

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL) primarily arising in the skin. Early diagnosis is difficult as the histology overlaps with features of inflammatory skin diseases. Even when the diagnosis is established there are no prognostic markers that predict whether the disease will be aggressive or indolent. Lastly, there are no curative treatments and MF will invariably relapse even after aggressive chemotherapy. The main objective of this study is to address the presence of intratumor heterogeneity in MF.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research