1013 Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection

Rejection is the primary barrier to broader implementation of vascularized composite allografts (VCA) including face& limb transplants. We studied human face transplant rejection by gene expression profiling, histology and immunostaining. Unique aspects of face transplant rejection reflected the unique immunologic characteristics of skin, a barrier tissue populated by immune cells and rich in anti-inflammatory& immunomodulatory pathways. Grade 1 rejection, defined by Banff criteria, did not differ significantly from non-rejection; we suggest Grade 1 rejection is not a pathologic state and can be treated with watchful waiting.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Translational Studies Source Type: research