1013 Immunoregulatory and lipid presentation pathways are upregulated in human face transplant rejection
Rejection is the primary barrier to broader implementation of vascularized composite allografts (VCA) including face& limb transplants. We studied human face transplant rejection by gene expression profiling, histology and immunostaining. Unique aspects of face transplant rejection reflected the unique immunologic characteristics of skin, a barrier tissue populated by immune cells and rich in anti-inflammatory& immunomodulatory pathways. Grade 1 rejection, defined by Banff criteria, did not differ significantly from non-rejection; we suggest Grade 1 rejection is not a pathologic state and can be treated with watchful waiting.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: T. Win, B. Dyring-Andersen, R. Lopdrup, J.E. Teague, V. Barrera, S. Ho Sui, N. Murakami, A. Chandraker, S. Tullius, B. Pomahac, L. Riella, R.A. Clark Tags: Translational Studies Source Type: research
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