New UCLA center focusing on disorders of the esophagus to be named for Robert G. Kardashian

TheDavid Geffen School of Medicine at UCLA has established a center for holistic, patient-centered treatment, research and education related to disorders of the esophagus.The new center is named in memory of Robert G. Kardashian, a prominent Los Angeles attorney who died of esophageal cancer in 2003. Kardashian ’s family will launch fundraising efforts to provide resources for the center’s key initiatives and activities.TheRobert G. Kardashian Center for Esophageal Health, which is based in the UCLA Vatche and Tamar Manoukian Division of Digestive Diseases, combines UCLA Health ’s collective expertise in gastroenterology, surgery, oncology, anesthesiology, radiology, pathology and pediatrics to gain new insights into the causes of these disorders and to develop new prevention and treatment strategies. The Robert G. Kardashian Center will collaborate with the Melvin and B ren Simon Digestive Diseases Center and the Manoukian Division’s Integrative Digestive Health and Wellness Program to provide individualized care to patients.“I am grateful for my friendship with the Kardashian family and this partnership, which will make a difference in patients’ lives for decades to come,” said Dr. Eric Esrailian, chief of the Manoukian Division of Digestive Diseases. “We hope the family’s commitment inspires even more suppor t from our community of friends — positioning the Robert G. Kardashian Center as a leader in the prevention...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Esophagologists and foregut surgeons have long debated the merits (or lack thereof) of antireflux surgery for GERD. Surgeons argue that proton pump inhibitors (PPIs) do not stop reflux, often require dose escalation, and have done little to decrease the frequency of Barrett ’s esophagus and are in part responsible for the rise in esophageal cancer.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Several studies reported an increase in lung and laryngeal cancers in patients with gastroesophageal reflux disease (GERD). The underlying mechanism is thought to be damage to the respiratory epithelium by gastric refluxate causing lung injury, chronic inflammation, and cancer promotion by activating proliferative signal pathways. Barrett ’s Esophagus (BE) is a manifestation of severe GERD. So, we wanted to examine the prevalence of respiratory cancers in BE patients and evaluate any predisposing factors.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
ConclusionsWe demonstrated the feasibility and safety of LECS for SMTs even on the EGJ. Fundoplication after LECS may be an approach for the prevention of postoperative reflux esophagitis. Future research is warranted to validate the efficacy of the addition of fundoplication.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
Obesity and esophageal cancer: GERD, Barrett´s esophagus, and molecular carcinogenic pathways. Expert Rev Gastroenterol Hepatol. 2020 May 22;:1-9 Authors: Schlottmann F, Dreifuss NH, Patti MG Abstract Introduction: Increases in the rates of esophageal adenocarcinoma (EAC) have paralleled rises in the prevalence of overweight and obesity. Despite not being fully understood, obesity-related EAC seems to have different carcinogenic pathways.Areas covered: This comprehensive review will thoroughly evaluate the current literature, describing the underlying mechanisms that help understanding the strong...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
AbstractBackgroundThe presence of Barrett ’s mucosa in the esophageal remnant is a result of post-esophagectomy anastomotic site exposure to gastric acid and is regarded as a human model of Barrett’s esophagus onset. Here, we attempted to clarify the relationship between duodenogastric reflux and formation of columnar epithelium by foll owing the changes over time after esophagectomy.MethodsA total of 96 patients underwent esophagectomy due to superficial cancer from April 2000 to March 2018 were included in this study. Cases were divided into two groups according to the reconstruction technique after esophagec...
Source: Esophagus - Category: Gastroenterology Source Type: research
Conclusions: A novel modified EG, the SPADE operation, has the potential to decrease gastroesophageal reflux following a PG. PMID: 32269846 [PubMed]
Source: Journal of Gastric Cancer - Category: Gastroenterology Tags: J Gastric Cancer Source Type: research
In this study, visual simulation scale and general comfort questionnaire developed by Kolaba, an American comfort nursing specialist, were used to evaluate the comfort level of the 2 groups of patients, including pain, acid reflux, upper abdominal burning sensation, and hiccup. Objective indexes such as height, body mass index, albumin value, electrolyte, wound healing, and pharyngeal fistula were used to evaluate the prognosis of the 2 groups of patients. The visual simulation scale can preliminarily judge the subjective feelings of patients. Trial registration: It has been registered at
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
AbstractPurpose of ReviewIn the early twentieth century, bronchiectasis (BE) was not a disease seen in the elderly population as life expectancy was usually
Source: Current Geriatrics Reports - Category: Geriatrics Source Type: research
The HUNT tool, M-BERET, or Kunzmann tool should be used rather than gastroesophageal reflux disease symptoms alone for identifying individuals who should be offered screening for esophageal cancer.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research
The landscape of gastroesophageal reflux disease (GERD) management is changing, in a good way. Several key forces have converged (Box  1), propelling us to see GERD with a new perspective. One of these forces is the expanding role of the interventional gastrointestinal endoscopist in foregut diseases, including GERD, Barrett’s and early esophageal cancer, achalasia, Zenker diverticulum, early gastric cancer, gastric outlet obst ruction, and obesity. Accordingly, when tapped by Dr Lightdale to be the editor of this issue devoted to GERD management, I had the privilege of assembling some of the top GERD authoritie...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Tags: Preface Source Type: research
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