Prognostic impact of worsening renal function in hospitalized heart failure patients with preserved ejection fraction -A report from the JASPER Registry-

Worsening renal function (WRF), generally defined as increased serum creatinine levels>0.3 mg/dL (26.5 µmol/L), is a well-known predictor of adverse prognosis in patients with heart failure (HF) with reduced ejection fraction (HFrEF).1-5 In hospitalized patients with HFrEF, WRF is associated with higher mortality and rehospitalization rates4, 5; nevertheless, aggressive decongestion, which achieves hemoconcentration, is associated with improved survival even in patients with WRF.6 On the other hand, compared to HFrEF, HF with preserved ejection fraction (HFpEF) has a different pathophysiology7, 8 and demonstrates different phenotypes, such as higher blood pressure and more comorbidities, such as hypertension and diabetes mellitus.

Source: Journal of Cardiac Failure - April 16, 2019 Category: Cardiology Authors: Yu Sato, Akiomi Yoshihisa, Masayoshi Oikawa, Toshiyuki Nagai, Tsutomu Yoshikawa, Yoshihiko Saito, Kazuhiro Yamamoto, Yasuchika Takeishi, Toshihisa Anzai Source Type: research