Population Pharmacokinetics of Clofarabine as Part of Pre-Transplant Conditioning in Pediatric Subjects Prior to Hematopoietic Cell Transplantation (HCT)

Although major advancements have been made in recent years through improvements in supportive care, high rates of engraftment failure and disease relapse remain prominent clinical problems in allogeneic hematopoietic cell transplantation (HCT). Historically, fludarabine has been included in most reduced intensity allogeneic HCT conditioning regimens in combination with an alkylating agent, such as busulfan (BuFlu). More recently, combining clofarabine with BuFlu has been evaluated in an attempt to improve efficacy in children undergoing alloHCT for the treatment of leukemia and various non-malignant disorders [1].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research