The roles of plant-derived Triptolide on non-small cell lung cancer.

The roles of plant-derived Triptolide on non-small cell lung cancer. Oncol Res. 2019 Apr 08;: Authors: Wei J, Yan Y, Chen X, Qian L, Zeng S, Li Z, Dai S, Gong Z, Xu Z Abstract Over the past decade, natural compounds have been proved to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb T. wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. Especially, an increasing number of studies have emphasized the anti-tumor effects of TPL on non-small cell lung cancer (NSCLC). Here, we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF-κB activation, suppression of miRNA expression, etc. In addition, the effect of TIG on immune response in cancer patients is summarized for improved immune modulation utilization. However, the clinical use of TPL is often limited by its severe toxicity and water-insolubility. Future clinical trials and drug delivery strategies are also to be discussed that will evaluate the security and validate the underlying the tumor-killing properties of TPL in human NSCLC. PMID: 30982492 [PubMed - as supplied by publisher]
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research