The impact of bacteremia on lipoprotein concentrations and patient ’s outcome: a retrospective analysis

AbstractBacteremia is a major clinical challenge requiring early treatment. Metabolic alterations occur during bacteremia, and accordingly plasma concentrations of lipoproteins LDL-C and HDL-C are substantially changed. We questioned whether bacteremia with Gram-negative versus Gram-positive bacteria causes contrasting changes of lipoprotein levels in order to differentiate between the 2-g stain types and if there is a relation with outcome parameters namely ICU-admission, 30-day mortality, duration of hospitalization. This is a retrospective dual-center cross-sectional study, including 258 patients with bacteremia. Plasma lipid levels were analyzed within 48  h to positive blood culture. Upon admission, HDL-C, LDL-C, and total cholesterol (p = 0.99) in plasma did not significantly differ between patients with Gram-negative and Gram-positive bacteremia, while significantly higher triglyceride concentrations were found in Gram-negative bacteremia (p <  0.05). 30-day mortality and ICU admission were associated with lower LDL-C and HDL-C concentrations as compared to survivors and non-ICU patients, and patients with HDL-C <  20 mg dl−1 and LDL-C  <  55 mg dl−1 had a relative risk (RR) of 2.85 for ICU therapy requirement and RR  = 2 of death within 30 days. Reduced HDL-C and LDL-C concentrations were associated with adverse patient’s outcome in bacteremia. Discrimination between Gram-negative and Gram-positive pathogens upon lipoprotein pa...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research