Repetitive transcranial magnetic stimulation ameliorates recognition memory impairment induced by hindlimb unloading in mice associated with BDNF/TrkB signaling

In conclusion, the data suggest that high frequency rTMS may be an effective countermeasure against the learning and memory deficiency, induced by simulated microgravity.Graphical abstractThe effect of 15 Hz rTMS on both Sham mice and HU miceIt shows that the sketch of recognition memory, synaptic plasticity and protein expressions represents the differences between HU mice and HU + rTMS mice. rTMS improves the recognition memory along with synaptic plasticity and increases the expressions of BDNF, TrkB, p-Akt, PSD95, NR2 A and NR2B in HU mice. The purple ‘‘−’’ implies that HU has merely a small effect on mice; the red ‘‘+’’ represents the enhancement effect of rTMS on HU mice.
Source: Neuroscience Research - Category: Neuroscience Source Type: research