Cancers, Vol. 11, Pages 509: Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Cancers, Vol. 11, Pages 509: Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization
Cancers doi: 10.3390/cancers11040509
Authors:
Young Eun Chon
Hana Park
Hye Kyung Hyun
Yeonjung Ha
Mi Na Kim
Beom Kyung Kim
Joo Ho Lee
Seung Up Kim
Do Young Kim
Sang Hoon Ahn
Seong Gyu Hwang
Kwang-Hyub Han
Kyu Sung Rim
Jun Yong Park
The neutrophil-to-lymphocyte ratio (NLR) has recently been reported to predict the prognosis of hepatocellular carcinoma (HCC). We explored whether NLR predicted the survival of patients with HCC undergoing transarterial chemoembolization (TACE), and developed a predictive model. In total, 1697 patients with HCC undergoing TACE as first-line therapy at two university hospitals were enrolled (derivation set n = 921, internal validation set n = 395, external validation set n = 381). The tumor size, tumor number, AFP level, vascular invasion, Child–Pugh score, objective response after TACE, and NLR, selected as predictors of overall survival (OS) via multivariate Cox’s regression model, were incorporated into a 14-point risk prediction model (SNAVCORN score). The time-dependent areas under the receiver-operating characteristic curves for OS at 1, 3, and 5 years predicted by the SNAVCORN score were 0.812, 0.734, and 0.700 in the derivation set. Patients were stratified into three risk group...
Source: Cancers - Category: Cancer & Oncology Authors: Young Eun Chon Hana Park Hye Kyung Hyun Yeonjung Ha Mi Na Kim Beom Kyung Kim Joo Ho Lee Seung Up Kim Do Young Kim Sang Hoon Ahn Seong Gyu Hwang Kwang-Hyub Han Kyu Sung Rim Jun Yong Park Tags: Article Source Type: research
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