Cancers, Vol. 11, Pages 509: Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization

Cancers, Vol. 11, Pages 509: Development of a New Nomogram Including Neutrophil-to-Lymphocyte Ratio to Predict Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization Cancers doi: 10.3390/cancers11040509 Authors: Young Eun Chon Hana Park Hye Kyung Hyun Yeonjung Ha Mi Na Kim Beom Kyung Kim Joo Ho Lee Seung Up Kim Do Young Kim Sang Hoon Ahn Seong Gyu Hwang Kwang-Hyub Han Kyu Sung Rim Jun Yong Park The neutrophil-to-lymphocyte ratio (NLR) has recently been reported to predict the prognosis of hepatocellular carcinoma (HCC). We explored whether NLR predicted the survival of patients with HCC undergoing transarterial chemoembolization (TACE), and developed a predictive model. In total, 1697 patients with HCC undergoing TACE as first-line therapy at two university hospitals were enrolled (derivation set n = 921, internal validation set n = 395, external validation set n = 381). The tumor size, tumor number, AFP level, vascular invasion, Child–Pugh score, objective response after TACE, and NLR, selected as predictors of overall survival (OS) via multivariate Cox’s regression model, were incorporated into a 14-point risk prediction model (SNAVCORN score). The time-dependent areas under the receiver-operating characteristic curves for OS at 1, 3, and 5 years predicted by the SNAVCORN score were 0.812, 0.734, and 0.700 in the derivation set. Patients were stratified into three risk group...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research