Nuclear Actin and Actin-Binding Proteins in DNA Repair.

Nuclear Actin and Actin-Binding Proteins in DNA Repair. Trends Cell Biol. 2019 Apr 03;: Authors: Hurst V, Shimada K, Gasser SM Abstract Nuclear actin has been implicated in a variety of DNA-related processes including chromatin remodeling, transcription, replication, and DNA repair. However, the mechanistic understanding of actin in these processes has been limited, largely due to a lack of research tools that address the roles of nuclear actin specifically, that is, distinct from its cytoplasmic functions. Recent findings support a model for homology-directed DNA double-strand break (DSB) repair in which a complex of ARP2 and ARP3 (actin-binding proteins 2 and 3) binds at the break and works with actin to promote DSB clustering and homology-directed repair. Further, it has been reported that relocalization of heterochromatic DSBs to the nuclear periphery in Drosophila is ARP2/3 dependent and actin-myosin driven. Here we provide an overview of the role of nuclear actin and actin-binding proteins in DNA repair, critically evaluating the experimental tools used and potential indirect effects. PMID: 30954333 [PubMed - as supplied by publisher]
Source: Trends in Cell Biology - Category: Cytology Authors: Tags: Trends Cell Biol Source Type: research