Thermodilution Cardiac Output: A Concept Over 250 Years in the Making

The need to quantify blood flow through the heart has led to the development of different techniques for its measurement. The 3 main approaches are the Fick method, dye dilution, and thermodilution techniques. The latter 2 are based on the use of indicators that indirectly quantify blood flow. These have slowly been developed over centuries, from the concept of measuring blood flow, to a technique, and its clinical utility. Thermodilution is the most popular dilution method used for measuring cardiac output (CO) in the clinical setting. The information obtained during this procedure is relevant in the process of clinical decision making in patients with critical illness, valvular heart disease, and congestive heart failure. The technique increased in popularity in the early 1970’s after Swan and Ganz invented the pulmonary artery catheter that simplified thermodilution enough to utilize it as a bedside procedure. This was only possible with simple yet clever engineering methods that are not commonly known in the medical community. Despite these advancements, the concept of measuring CO by dilution techniques is one where its optimal use in the clinical setting continues to be an area of investigation. The thermodilution concept and the mechanism of measuring CO will be discussed in the following review.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research

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Authors: Lehto HR, Pietilä A, Niiranen TJ, Lommi J, Salomaa V Abstract Aims: To compare diabetic patients with coronary heart disease (CHD) needing revascularization to corresponding non-diabetic patients in terms of revascularization methods, comorbidities and urgency of procedure. We also examined the impact of patient characteristics and comorbidities on the revascularization method.Methods: We identified all diabetic (n = 33,018) and non-diabetic (n = 106,224) patients with first-ever, percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) from electr...
Source: Annals of Medicine - Category: Internal Medicine Tags: Ann Med Source Type: research
RARITAN, NJ, May 13, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today results from the final analysis of the pivotal Phase 3 SPARTAN study demonstrating ERLEADA® (apalutamide) in combination with androgen deprivation therapy (ADT) significantly improved overall survival (OS), compared to ADT alone, in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) who were at high risk of developing metastases.[i] Results will be presented at the American Society of Clinical Oncology (ASCO) Virtual Scientific Program (Abstract #5516) beginning May 29th. ERLEADA® i...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
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Source: Quality of Life Research - Category: Health Management Source Type: research
AbstractEarly recognition and timely management of cyanotic congenital heart disease (CCHD) is necessary for good outcome. CCHD is an umbrella term encompassing many diseases with variable pathophysiology, which determines clinical presentation of CCHD. Conditions like total anomalous pulmonary venous connection (TAPVC) and transposition of great arteries (TGA) usually present in neonatal period. Tetralogy of Fallot (TOF) and related conditions present with squatting, cyanotic spells and silent chest with no evidence of congestive heart failure, whereas transposition physiology presents with congestive heart failure with cyanosis.
Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
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Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Expert Rev Respir Med Source Type: research
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Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
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Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Heart Health Hypertension and Stroke Infectious diseases Source Type: blogs
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs
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Source: Indian Journal of Pediatrics - Category: Pediatrics Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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