Advances in Epidemiological Methods and Utilisation of Large Databases: A Methodological Review of Observational Studies on Central Nervous System Drug Use in Pregnancy and Central Nervous System Outcomes in Children

ConclusionMultiple factors, including different study designs and data sources, have led to inconsistent findings in associations between CNS drug use in pregnancy and CNS outcomes in children. Researchers should allow for study designs with clearly defined exposure periods, at the very least in trimesters, and use advanced confounding adjustment methodology to increase the accuracy of the findings.
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research

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By Anna-Maija Mattila-Litvak, Supervisory Development Outreach and Communications Officer Anita Nakazibwe holds her daughter Emmanuela. While mom is HIV-positive, the toddler remains HIV-negative —a fact that brings Anita great joy. Photo by Anna-Maija Mattila-Litvak, USAID/Uganda.February 17, 2020“My first treatment was a smile!” says Anita Nakazibwe about the welcome she got when she first came to Moroto Regional Referral Hospital in eastern Uganda. Anita holds her year-and-a-half-old baby girl Emmanuela in her arms and is beaming. She gave birth at the hospital to a healthy baby, although she herse...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: HIV & AIDS Maternal, Newborn, Child Health Nurses Source Type: news
BACKGROUND: Childhood abuse has a negative effect on mental health during pregnancy; however, the association between childhood abuse and suicide ideation has received relatively little attention. METHOD: Women at 28 weeks or more into their pregna...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 17 February 2020Source: Evolution and Human BehaviorAuthor(s): Yong Zhi Foo, Leigh W. Simmons, David I. Perrett, Patrick G. Holt, Peter R. Eastwood, Gillian RhodesAbstractEvolutionary theories suggest that humans prefer sexual dimorphism in faces because masculinity in men and femininity in women may be an indicator of immune function during development. In particular, the immunocompetence handicap hypothesis proposes that sexual dimorphism indicates good immune function during development because the sex hormones, particularly testosterone in men, required for the development of sexually...
Source: Evolution and Human Behavior - Category: Psychiatry & Psychology Source Type: research
This study aims to compare the clinical course of peripartum cardiomyopathy (PPCM) cohorts from Germany (G ‐PPCM) and South Africa (SA‐PPCM) with fibrosis‐related markers to get insights into novel pathomechanisms of PPCM.Methods and resultsG ‐PPCM (n = 79) and SA ‐PPCM (n = 72) patients and healthy pregnancy ‐matched women from Germany (n = 56) and South Africa (n = 40) were enrolled. Circulating levels of procollagen type ‐I (PINP) and type‐III (PIIINP) N‐terminal propeptides, soluble ST2, galectin‐3, and full‐length and cleaved osteopontin (OPN) were measured at diagnosis (baseline) and 6 months of...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
[New Times] A few days ago, First Lady Jeannette Kagame addressed fellow African First Ladies who had gathered in Addis Ababa, Ethiopia and voiced her concern about growing gaps in parent-child communication, limited access to sexual reproductive health information and quality services that continue to sabotage efforts to deliver the Africa that the continent's youth deserve.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
Discussion Myasthenia gravis (MG) is a problem of the neuromuscular junction which causes muscle weakness. It can occur in all ages and have a range of symptoms from mild localized disease to mortality-threatening respiratory failure. MG occurs in 1.7-30 cases/million, with a prevalence of 77.7 cases/million. Pediatric patients comprise 10-15% of all patients with MG. In various Asian populations, the juvenile MG can be up to 50% of all of the MG cases. Fluctuations in muscle weakness is a hallmark of the disease. As a reminder, “[i]n normal synaptic transmission in the neuromuscular junction, the axon is depolarize...
Source: - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
The torsion of normal adnexa is rare during pregnancy, especially in the third trimester. Nonspecific symptoms and signs as well as the limitations of ultrasound (US) make the diagnosis difficult, resulting in...
Source: BMC Medical Imaging - Category: Radiology Authors: Tags: Case report Source Type: research
This population-based cross-sectional study assesses whether antenatal transfer of pregnant women to a level III hospital in a perinatal network is associated with reduced neonatal mortality in infants born very preterm.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
Regionalization of perinatal care has long been known to improve neonatal outcomes. The March of Dimes, in their original iteration of Toward Improving the Outcome of Pregnancy in 1976, strongly advocated for regionalized perinatal care and development of levels of neonatal care. In response, health care systems created regional perinatal networks to facilitate antenatal transfer of women at risk for preterm birth in the hopes of improving neonatal outcome and maternal care. In the 1990s, with the advent of managed care and expansion of Medicaid reimbursement, hospitals sought to control costs within systems. These changes...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
DiscussionIf outpatient balloon-catheter induction reduces caesarean section rates, has additional clinical benefits, and is safe, cost-effective, and acceptable to women and clinicians, we anticipate change in induction of labour practice around the world. We think that home-based balloon-catheter induction will be welcomed as part of a patient-centred labour-induction care package for pregnant women.Trial registrationAustralia New Zealand Clinical Trials Registry (ANZCTR), ACTRN:12616000739415. Registered on 6 June 2016.
Source: Trials - Category: Research Source Type: clinical trials
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