Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study.

Sensory Qualities Point to Different Structural and Functional Skin Patterns in Chronic Pruritus Patients. A Translational Explorative Study. Acta Derm Venereol. 2019 Apr 02;: Authors: Hidding J, Agelopoulos K, Pereira MP, Conrad H, Hatt H, Lotts T, Osada N, Pogatzki-Zahn E, Schmelz M, Ständer S Abstract Chronic pruritus (CP) is often accompanied by paresthetic sensations like warmth, burning and stinging. The aim of this study was to analyze, whether divergent sensations are linked to structural and functional skin alterations in clinically diagnosed CP patients. Clinical responses to capsaicin, histamine, and to thermal and mechanical stimulation, intraepidermal nerve fiber density, and epidermal expression of transient receptor potential (TRP)-channels were investigated in healthy controls, and in CP patients, reporting either warmth (CP-W) or neuropathic sensations (CP-N). In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density. CP-N showed earlier onset of sensations after capsaicin stimulation, significantly increased warmth detection threshold, and higher epidermal expression of TRPV4 compared to healthy controls. The present study contributes to the neurobiological understanding of the divergence of sensory sensations in CP, indicating new treatment targets. ...
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. Int J Lab Hematol. 2019 Aug;41(4):448-455 Authors: Van der Beken Y, Van Dalem A, Van Moer G, Segers E, Damiaens S, Hoffmann J, Lakos G, Jochmans K Abstract INTRODUCTION: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium. METHODS: Within-run and within-laboratory imprecision, linearity, and carryover were assessed usi...
Source: International Journal of Laboratory Hematology - Category: Hematology Authors: Tags: Int J Lab Hematol Source Type: research
We present here a review of studies on peripheral and neurophysiological markers in SCA3/MJD that can be candidates for state biomarkers. Data on markers already studied were summarized, giving emphasis on validation against clinical scale, and responsiveness to change. While some biological fluid compounds and neurophysiological parameters showed poor responsiveness, others seemed to be good candidates. Some potential candidates that are waiting for responsiveness studies were serum levels of neuron specific enolase, vestibulo-ocular reflex and video-oculography. Candidates evaluated by RNA and microRNA expression levels ...
Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
ABSTRACT Duchenne de Boulogne is known mainly by the disease eponymously named “ Duchenne muscular dystrophy ” , or pseudohypertrophic muscular dystrophy, although some experts consider that the original description of this disease does not belong to him. Less well known are the facts related to the tragic death of his beloved wife shortly after the birth of his only child, the unjustifiable distance he was forced to keep from this son for more than 30 years, and of being humiliated and professionally despised by his peers. These events made the life of this physician, physiologist, researcher and inventor extr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ABSTRACT Duchenne de Boulogne is known mainly by the disease eponymously named “ Duchenne muscular dystrophy ” , or pseudohypertrophic muscular dystrophy, although some experts consider that the original description of this disease does not belong to him. Less well known are the facts related to the tragic death of his beloved wife shortly after the birth of his only child, the unjustifiable distance he was forced to keep from this son for more than 30 years, and of being humiliated and professionally despised by his peers. These events made the life of this physician, physiologist, researcher and inventor extr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
ABSTRACT Duchenne de Boulogne is known mainly by the disease eponymously named “ Duchenne muscular dystrophy ” , or pseudohypertrophic muscular dystrophy, although some experts consider that the original description of this disease does not belong to him. Less well known are the facts related to the tragic death of his beloved wife shortly after the birth of his only child, the unjustifiable distance he was forced to keep from this son for more than 30 years, and of being humiliated and professionally despised by his peers. These events made the life of this physician, physiologist, researcher and inventor extr...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Abstract Background: Resting sympathetic hyperactivity and impaired parasympathetic reactivation after exercise have been described in patients with heart failure (HF). However, the association of these autonomic changes in patients with HF and sarcopenia is unknown. Objective: The aim of this study was to evaluate the impact of autonomic modulation on sarcopenia in male patients with HF. Methods: We enrolled 116 male patients with HF and left ventricular ejection fraction
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Twenty six participants representing patients, funding agencies and basic and clinical scientists involved in research into skeletal muscle stem cells and muscular dystrophies from France, Germany, Italy, India, UK, Australia, Spain, USA, The Netherlands and Switzerland met in Hoofddorp, The Netherlands on 25 – 27 January 2019. The meeting was held under the auspices of the ENMC and ENMC main sponsors, with the additional support of Muscular Dystrophy UK.
Source: Neuromuscular Disorders - Category: Neurology Authors: Tags: Workshop report Source Type: research
Condition:   Myotonic Dystrophy 1 Intervention:   Other: Training program Sponsors:   Élise Duchesne;   Fondation du Grand défi Pierre Lavoie Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Bethlem Myopathy;   Ullrich Congenital Muscular Dystrophy 1, Digenic, Col6A1/Col6A2;   Ullrich Congenital Muscular Dystrophy 1, Autosomal Recessive;   Ullrich Congenital Muscular Dystrophy 1, Autosomal Dominant;   Bethlem Myopathy 1, Autosomal Recessive;   UCMD;   BTHLM1 Intervention:   Other: Patient Registry Sponsor:   Newcastle-upon-Tyne Hospitals NHS Trust Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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