Multi-transcriptomes analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology.

Multi-transcriptomes analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology. Am J Physiol Gastrointest Liver Physiol. 2019 Mar 28;: Authors: Chen W, Wu X, Yan X, Xu A, Yang A, You H Abstract Elimination or suppression of causative factors can raise the possibility of liver fibrosis regression. However, different injurious stimuli will give fibrosis from somewhat different etiologies, which, in-turn, may hamper the discovery of liver fibrosis-specific therapeutic drugs. Therefore, the analogical cellular and molecular events shared by various etiologies-evoked liver fibrosis should be clarified. Our present study systematically integrated five public available transcriptomic datasets regarding liver fibrosis with different etiologies from Gene Expression Omnibus (GEO) database, and performed a series of bioinformatics analyses and experimental verifications. A total of 111 significantly up-regulated and 16 down-regulated genes were identified specific to liver fibrosis independent of any etiology. These genes were predominately enriched in some KEGG pathways including "PI3K-AKT signaling pathway", "Focal adhesion" and "ECM-receptor interaction". Subsequently, 5 prioritized liver fibrosis-specific genes including COL4A2, THBS2, ITGAV, LAMB1 and PDGFRA were screened. These genes were positively associated with each other and liver fibrosis progression. In addition, they could ro...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research