TCF21 inhibits tumor-associated angiogenesis and suppresses the growth of cholangiocarcinoma by targeting PI3K/Akt and ERK signaling.

CONCLUSIONS: TCF21 presents anti-angiogenic activities and thus, elevating TCF21 expression may provide therapeutic benefits for CCA.
PMID: 30920845 [PubMed - as supplied by publisher]

Source: Am J Physiol Gastroi... - March 27, 2019 Category: Gastroenterology Authors: Duan HX, Li BW, Zhuang X, Wang LT, Cao Q, Tan LH, Qu GF, Xiao S Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research