Ten Years of Robotripping: Evidence of Tolerance to Dextromethorphan Hydrobromide in a Long-Term User.

We report a patient with persistent dextromethorphan hydrobromide abuse at escalating doses whose mean serum chloride concentration increased, on average, by 0.00232 mEq/L every day over a 110-month period. This case demonstrates progressive spurious hyperchloremia secondary to bromide interference in hospital-based chloride assays, supporting the patient's reported need to dose escalate to the same desired effect. Although this artefactual laboratory finding is a well-documented result of bromide ingestion, it may be useful in identifying patterns of dextromethorphan hydrobromide use that suggest tolerance. PMID: 30903576 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30903576?dopt=Abstract

Source: Journal of Medical Toxicology - March 21, 2019 Category: Toxicology Authors: Olives TD, Boley SP, LeRoy JM, Stellpflug SJ Tags: J Med Toxicol Source Type: research