SDF ‑1/CXCR4 induces epithelial‑mesenchymal transition through activation of the Wnt/β‑catenin signaling pathway in rat chronic allograft nephropathy.

In conclusion, SDF‑1/CXCR4 induces EMT of renal tubular epithelial cells with the involvement of the Wnt pathway, which may be a novel mechanism and therapeutic target in kidney allograft fibrosis of rats. PMID: 30896799 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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AbstractBackgroundThe interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation has not been evaluated directly. PTA, defined by WHO/AST criteria, was investigated in 1307 adult kidney transplant recipients between 2000 and 2015 (median follow-up, 7  years).MethodsWe investigated the impact of hemoglobin (Hb) on graft failure (non-censored for death) and their interactions, time-dependent Cox model, and subgroup analysis were used.ResultsPTA prevalence was 43.6% at 7  years and varied according to allograft function, recipient sex, and follow-up period. Decreased Hb conside...
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
In this study, we compare the ability of suboptimal doses of freshly sorted and in vitro expanded human CD127loCD25+CD4+ Tregs to promote human skin allograft survival and demonstrate that higher effectiveness of expanded Tregs can be compensated by transient activation of freshly isolated Tregs. Recently-activated Tregs are characterized by an increased expression of Treg functional markers and better in vitro and in vivo survival, correlating with an increased expression of anti-apoptotic BCL-XL. The ability to enhance Treg function without long in vitro culture may be of value in the treatment of specific immunopatholog...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Mauricio Campos-Mora1,2, Pamina Contreras-Kallens1, Felipe Gálvez-Jirón1, Masyelly Rojas1, Carolina Rojas3, Aarón Refisch1, Oscar Cerda2,4 and Karina Pino-Lagos1* 1Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Las Condes, Chile 2Programa de Biología Celular y Molecular, Facultad de Medicina, Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile 3Facultad de Odontología, Universidad de Chile, Santiago, Chile 4Millennium Nucleus of Ion Channel Associated Diseases (MiNICAD), Universidad de Chile, San...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions: Pre-transplantation plasmatic miR-155-5p expression may be useful for stratifying low-immunologic-risk patients, and post-transplantation miR-181a-5p and miR-155-5p may be candidates for inclusion in early, non-invasive prognostic biomarker panels to prevent TCMAR or SCR and better identify patient candidates for IS minimization. Large prospective randomized multicenter trials are needed to refine the cut-off values and algorithms and validate the clinical usefulness of these biomarkers. Introduction Despite great advances in immunosuppressive (IS) therapy, T cell-mediated rejection (TCMAR), which is the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We examined clinically approved nerve conduits containing collagen and polyglycolic acid (PGA ‐c) combined with collagen‐binding basic fibroblast growth factor (bFGF) containing a polycystic kidney disease (PKD) domain and collagen binding domain (CBD) (bFGF‐PKD‐CBD) in a rat 15‐mm sciatic nerve critical‐size defect model. The treatment groups were: PGA‐c immersed in phosphate‐ buffered saline (PBS) (PGA‐c/PBS group), bFGF (PGA‐c/bFGF group), or bFGF‐PKD‐CBD (PGA‐c/bFGF‐PKD‐CBD group), and no treatment (Defect group). Gait and histological analyses were performed. Four weeks after treatment, t...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: Original Research Report Source Type: research
We report a case of a young male who underwent live related kidney transplant but lost the graft on the operating table due to renal vein thrombosis (RVT). PMID: 30992742 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
In this study, posttransplant thrombocytopenia was defined as a 30% reduction in platelet count from the baseline in the first week or a decrease of
Source: Transplant Immunology - Category: Transplant Surgery Authors: Tags: Transpl Immunol Source Type: research
Qiancheng Deng1, Yangyang Luo1,2, Christopher Chang3, Haijing Wu1, Yan Ding4* and Rong Xiao1* 1Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China 2Department of Dermatology, Hunan Children's Hospital, Changsha, China 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United States 4Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, China Autoimmune diseases are usually complex and multifactorial, characterized by aberrant produc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Jiayu Liang, Yongquan Tang, Zhihong Liu, Xianding Wang, Liangyou Tang, Zijun Zou, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping LuAbstractAimsIncreasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and ver...
Source: Life Sciences - Category: Biology Source Type: research
Abstract OBJECTIVES: BK virus is a polyomavirus that can cause nephropathy and graft loss after kidney transplant. The aim of our study was to screen the BK viremia prevalence, to understand the value of the inter-vention for BK virus nephropathy, and to determine the risk factors associated with BK viremia after kidney transplant in our center. MATERIALS AND METHODS: Our retrospective cross-sectional study included 91 adult kidney transplant recipients who were seen between 2015 and 2017 and who had follow-up from 1 month to over 2 years. BK viremia was evaluated by use of plasma quantitative polymerase chai...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
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