(112) Childhood Adversity Linked to Heightened Pain Sensitivity in Adults

Childhood experiences of adverse social conditions have demonstrated lifelong downstream health-related consequences. Since more exposure to adverse childhood events (ACEs) are associated with poorer outcomes, their exposure can be considered a social determinant of health and wellness. The mechanism of ACEs contributing to adverse health consequences may lie in chronic activation of the stress pathway, leading to dysregulation of the neuroendocrine, immune, and autonomic systems. Chronic stress, experienced in childhood, appears to change the physiologic response to subsequent stress, perhaps though HPA and immune axes.

Source: The Journal of Pain - March 21, 2019 Category: Materials Science Authors: R. Sheinberg, C. Campbell, A. Kearson, E. Burton, J. Letzen Source Type: research