Combined estrogen-progestin pill is a safe and effective option for endometrial hyperplasia without atypia: a three-year single center experience.

CONCLUSION: For the first time we demonstrate that OCP is an effective therapy for non-atypical EH and is associated with higher remission rate compared with oral progestin. Reproductive outcomes are reassuring and comparable between the two groups. PMID: 30887764 [PubMed - in process]
Source: Journal of Gynecologic Oncology - Category: OBGYN Tags: J Gynecol Oncol Source Type: research

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Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study provides an update and comprehensive evidence to support the observation that despite the fact that PCOS patients achieve better clinical pregnancy rate and live birth rate, physicians should continue to consider patients with PCOS to be high risk of adverse pregnancy-related outcomes.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
AbstractStudy objectiveTo compare pregnancy outcomes in PCOS women undergoing transvaginal ovarian injury (TVOI) and laparoscopic ovarian drilling (LOD)Design126 infertile patients with PCOS were included in this prospective cohort studyCanadian task force classification of level of evidenceIIA.SettingUniversity-affiliated fertility center.PatientsSixty-seven infertile patients with the history of failed in vitro maturation underwent follow-up as the TVOI group. Fifty-nine infertile women who underwent LOD acted as controls. All subjects had PCOS with menstrual irregularity and were anovulatory by repetitive serum progeste...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ni ME Abstract Context: There is increasing evidence for MIS/AMH physiologic activity in the human uterus, so it is relevant to study how MIS/AMH levels impact pregnancy. Objective: To investigate the association of MIS/AMH levels with risk of adverse obstetric outcomes. Design: Retrospective cohort study. Setting: Academic fertility center. Patients: Women who became pregnant through in vitro fertilization (IVF) between January 2012-October 2016. Exclusion criteria were: oocyte donation, gestational carrier, multiple gestation, miscarriage before 20 weeks, medically indicated preterm deliverie...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Publication date: Available online 6 January 2018Source: Middle East Fertility Society JournalAuthor(s): Kamal M. Zahran, Waleed A. Mostafa, Ahmed M. Abbas, Mansour A. Khalifa, Gamal H. SayedAbstractObjectiveTo compare the effect of adjunctive use of cabergoline with clomiphene citrate (CC) in infertile polycystic ovarian syndrome (PCOS) patients with normal prolactin level.Study designA randomized clinical trial (NCT 02644304).SettingAssiut University Hospital, Assiut, Egypt.Materials and methodsInfertile euprolactinemic PCOS patient were recruited and randomized in a 1:1 ratio to CC plus cabergoline or CC alone. All pati...
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
CONCLUSIONS: Primary infertility, T2DM familial history, hypertriglyceridemia, low cholesterol-HDL, older age, waist circumference> 80 cm, and high LH may confer poorer fertility treatment results. PMID: 29944229 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Conclusions The use of cabergoline with CC in induction of ovulation in euprolactinemic infertile women with PCOS results in high ovulation rate, high pregnancy rate as compared to use of CC alone.
Source: Middle East Fertility Society Journal - Category: Reproduction Medicine Source Type: research
In this study, we compared thein vitro fertilization and embryo transfer (IVF-ET) results of 22 patients with PCOS and 25 patients with tubal factor infertility and detected the ROS levels in the GCs of these two groups. Results showed that the PCOS group had significantly larger follicles on the administration day for human chorionic gonadotropin than the tubal factor group (P 0.05). PCOS group had slightly lower fertilization, cleavage, grade I/II embryo, clinical pregnancy, and implantation rates and higher miscarriage rate than the tubal factor group (P> 0.05). We further found a significantly higher ROS level of GC...
Source: Frontiers of Medicine - Category: General Medicine Source Type: research
ConclusionPregnant women with pre‐gestational diabetes on metformin are at a higher risk for adverse pregnancy outcomes than the general population. This appears to be due to the underlying diabetes since women on metformin for other indications do not present meaningfully increased risks.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUG SAFETY Source Type: research
Conclusion(s) Letrozole-low dose gonadotropins combination appears to be effective across different causes of infertility for superovulation. The letrozole-low dose gonadotropin combination resulted in high rate of monofolliculogenesis, low occurrence of multiple gestations and no case of OHSS or cycle cancellation.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
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