Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice.

Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice. Zygote. 2019 Mar 19;:1-10 Authors: Zheng Y, Zhang P, Zhang C, Zeng W Abstract SummaryCryptorchidism, characterized by the presence of one (unilateral) or both (bilateral) undescended testes, is a common male urogenital defect. Cryptorchidism can lead to male infertility, testicular cancer being the most extreme clinical symptom, as well as psychological issues of the inflicted individual. Despite this, both knowledge about the aetiology of cryptorchidism and the mechanism for cryptorchidism-induced male infertility remain limited. In this present study, by using an artificial cryptorchid mouse model, we investigated the effects of surgery-induced cryptorchidism on spermatogenic cells and seminiferous epithelial cycles. We found that surgery-induced cryptorchidism led to a reduced testicular weight, aberrant seminiferous epithelial cycles and impaired spermatogenesis characterized by degenerating spermatogenic cells. We also observed multinucleated giant cells after surgery-induced cryptorchidism. Transmission electron microscopy, terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) and western blot assays demonstrated cryptorchidism-induced apoptosis of spermatogenic cells. Moreover, we identified the occurrence of autophagy in germ cells after surgery-induced cryptorchidism. Interestingly, apoptosis and autophagy were synchronous, suggestive o...
Source: Zygote - Category: Reproduction Medicine Authors: Tags: Zygote Source Type: research

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Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
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Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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Source: NIH Calendar of Events - Category: American Health Source Type: events
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Source: NIH Calendar of Events - Category: American Health Source Type: events
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