Editors ’ Picks

Tumor development may be suppressed by the immune system via elimination of cancer cells or via prevention of cancer cell outgrowth. The existence of CD8+CD69+CD103+ tissue resident memory T cells (TRM) and their known role in immune surveillance led Park and colleagues to investigate whether this cell population mediated immunity to epidermis-derived melanoma. Using a mouse model of transplantable melanoma, these investigators demonstrated that tissue-resident TRM established a dynamic melanoma-immune equilibrium in the epidermis, suppressing macroscopic tumor development.
Source: Journal of Investigative Dermatology - Category: Dermatology Tags: Editorial Source Type: research