Updates on the epigenetic roles of sirtuins.

Updates on the epigenetic roles of sirtuins. Curr Opin Chem Biol. 2019 Mar 12;51:18-29 Authors: Kosciuk T, Wang M, Hong JY, Lin H Abstract Sirtuins are a class of enzyme with NAD+-dependent protein lysine deacylase activities. They were initially discovered to regulate transcription and life span via histone deacetylase activities. Later studies expanded their activities to other proteins and acyl lysine modifications. Through deacylating various substrate proteins, they regulate many biological processes, including transcription, DNA repair and genome stability, metabolism, and signal transduction. Here, we review recent understandings of the epigenetic functions (broadly defined to include transcriptional, post-transcriptional regulation, and DNA repair) of mammalian sirtuins. Because of the important functions of sirtuins, their own regulation is of great interest and is also discussed. PMID: 30875552 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research