Emergence of a Specific Intrapulmonary CD4+ T Cell Subset Prior to the Onset of Lung Allograft Dysfunction

We have applied cutting-edge mass cytometry (MC) technology to serial bronchoalveolar lavage (BAL) cells obtained from lung transplant recipients (LTRs) and have used it to compare the cellular composition of the BAL compartment in patients who remain stable or go on to develop lung allograft dysfunction (LAD), defined here as a drop, from any cause, in the forced expiratory volume in 1 second of 20% from the best post-transplant baseline value.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 17 Source Type: research

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Qiancheng Deng1, Yangyang Luo1,2, Christopher Chang3, Haijing Wu1, Yan Ding4* and Rong Xiao1* 1Hunan Key Laboratory of Medical Epigenetics, Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China 2Department of Dermatology, Hunan Children's Hospital, Changsha, China 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, Davis, CA, United States 4Department of Dermatology, Hainan Provincial Dermatology Disease Hospital, Haikou, China Autoimmune diseases are usually complex and multifactorial, characterized by aberrant produc...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 17 April 2019Source: Life SciencesAuthor(s): Jiayu Liang, Yongquan Tang, Zhihong Liu, Xianding Wang, Liangyou Tang, Zijun Zou, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping LuAbstractAimsIncreasing evidence has shown the diagnostic value of miR-155 in organ transplantation. The dysregulation of miR-155 is reported to be associated with development of acute or chronic complications in solid organ transplant recipients. Here, we summarized related evidence to explore the correlation between the dysregulation of miR-155 and various allograft dysfunction in transplant recipients, and ver...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: Mesenchymal stem cell transplantation could be use as a potential treatment for PHLF. Introduction Partial hepatectomy is an important treatment for benign and malignant liver diseases. Although the liver can be completely regenerated after partial excision or injury, at least 1/3 of the liver should be retained in most of the patients, and 40–50% should be retained in patients with parenchymal liver disease (Adams et al., 2013; Cieslak et al., 2014). Postoperative complications, such as acute post-hepatectomy liver failure (PHLF) or small liver syndrome, may occur when the scope of excision is to...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In conclusion, the number of donor-specific IL-21 pc is associated with an increased risk of both early and late rejection, giving it the potential to be a new biomarker in kidney transplantation. Introduction Interleukin (IL)-21 is a pro-inflammatory cytokine and is produced by several T lymphocytes, including CD4+, T follicular helper (Tfh) and T-helper 17 (Th17) cells (1, 2). Natural killer T cells (NKT) cells and CD8+ T cells can also produce IL-21 (3–5). IL-21 has a diverse effect on a broad range of immune cells. IL-21 drives T and B cell dependent responses. This pleiotropic cytokine is crucial for T ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The outcomes of transplantation vary widely by organ. Lung transplantation (LTx) has rather poor long-term outcome, with a current median post-transplant survival of 6.0years.1,2 Survival after organ transplantation is limited by both graft-related and non ‒graft-related factors. Allograft failure remains the leading cause of morbidity and mortality across all organ groups and is the major cause of death, accounting for>40% of deaths beyond the first year post-LTx.1,2
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: EDITORIAL Source Type: research
The term “chronic lung allograft dysfunction” (CLAD) has previously been introduced to identify patients with persistent pulmonary function decline after lung transplantation. Initially, CLAD was used as an umbrella term and encompassed all possible causes of pulmonary function decline, not only chronic rejection. Since chronic rejection has recently been phenotyped in bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and in a mixed phenotype, and because of different interpretations of the current CLAD definition, the Pulmonary Council of the International Society for H eart and Lun...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
The term “restrictive allograft syndrome” (RAS) was recently introduced to identify a specific phenotype of chronic lung allograft dysfunction (CLAD), that was characterized by restrictive pulmonary physiology and worse survival compared to the more common bronchiolitis obliterans syndrome (BOS). Since t he definition of RAS is not clear cut at present, the Pulmonary Council of the International Society for Heart and Lung Transplantation gathered a group of experts in the field with the primary aim to formulate a strict and useful definition of RAS.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Fibrosis is a universal finding in chronic allograft dysfunction, and it is characterized by an accumulation of extracellular matrix. The precise source of the myofibroblasts responsible for matrix deposition is not understood, and pharmacological strategies for prevention or treatment of fibrosis remain limited. One source of myofibroblasts in fibrosis is an endothelial-to-mesenchymal transition (EndMT), a process first described in heart development and involving endothelial cells undergoing a phenotypic change to become more like mesenchymal cells. Recently, lineage tracing of endothelial cells in mouse models allowed s...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
We examined the ratio of regulatory T cells (Tregs, which express Foxp3) to T effector cells (Teff) in TBBx as a predictor of outcome.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 16 Source Type: research
Long-term survival after lung transplantation (LTx) is hampered by chronic lung allograft dysfunction, with bronchiolitis obliterans syndrome (BOS) as its most common phenotype. Bronchiectasis (BRECT), hyperinflation and airtrapping are considered the key features of BOS on chest CT. We investigated whether chest CT and key features have prognostic value at BOS diagnosis in patients with established BOS after LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 15 Source Type: research
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