Obesity Leads to Increased IL-18, Treg Impairment and Increased Risk of PGD

Lung transplantation (Tx) is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD) in the first few days post-Tx. PGD mainly involves hyperactivation of innate immunity, but as CD4+FOXP3+ T-regulatory (Treg) cells can curtail various types of inflammation, we wondered whether patients who develop PGD might have dysfunctional Treg cells.

Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: T. Akimova, T. Zhang, U.H. Beier, A. Samanta, R. Han, L. Wang, J. Jiao, J.M. Diamond, D.S. Wilkes, D.J. Lederer, R.A. Simmons, J.D. Christie, W.W. Hancock Tags: 822 Source Type: research