Brain-eating amoebae infection: challenges and opportunities in chemotherapy.

Brain-eating amoebae infection: challenges and opportunities in chemotherapy. Mini Rev Med Chem. 2019 Mar 13;: Authors: Mungroo MR, Anwar A, Khan NA, Siddiqui R Abstract Pathogenic free-living amoeba are known to cause devastating infection of the central nervous system and are often referred to as "brain-eating amoebae". The mortality rate of more than 90% and free-living nature of these amoebae is a cause for concern. It is distressing that the mortality rate has remained the same over the past few decades highlighting lack of interest by the pharmaceutical industry. With the threat of global warming and increased outdoor activities of public, there is a need for renewed interest in identifying potential anti-amoebic compounds for successful prognosis. Here, we discuss the available chemotherapeutic options and opportunities of potential strategies in the treatment and diagnosis of these life-threatening infections. PMID: 30868950 [PubMed - as supplied by publisher]
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research