Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration

In this study, we evaluated the direct bone effects of CaSR activation by a calcimimetic (AMG 641) in  vitro and in vivo. To create a PTH “clamp,” total parathyroidectomy was performed in rats with and without uremia induced by 5/6 nephrectomy, followed by a continuous subcutaneous infusion of PTH.

Source: Kidney International - March 10, 2019 Category: Urology & Nephrology Authors: Juan M. D íaz-Tocados, María E. Rodríguez-Ortiz, Yolanda Almadén, Carmen Pineda, Julio M. Martínez-Moreno, Carmen Herencia, Noemi Vergara, M. Victoria Pendón-Ruiz de Mier, Rafael Santamaría, Cristian Rodelo-Haad, Antonio Casado-Díaz, Víctor Loren Tags: Basic Research Source Type: research