Antitussive therapy: A role for levodropropizine

Publication date: Available online 11 March 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Surinder Birring, Francesco de Blasio, Peter Dicpinigaitis, Giovanni Fontana, Luigi Lanata, Clive Page, Federico Saibene, Alessandro ZanasiAbstractCough is a protective reflex that serves to clear the airways of excessive secretions and foreign matter and which sometimes becomes excessive, and troublesome to patients. Cough is one of the most common reasons why individuals seek medical attention. A range of drugs have been developed in the past with antitussive activity and different mechanisms of action, but there are still very few safe and effective treatments available. The poor tolerability of most available antitussives is closely related to their action on the central nervous system (CNS). An international group of experts specialized in cough met to discuss the need to identify an effective antitussive treatment with a good tolerability profile.The aim of this expert review is to increase the knowledge about the cough mechanism and the activity of levodropropizine, a peripherally acting antitussive drug.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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ConclusionsALS individuals demonstrated increased sensitivity to an upper airway irritant; however, they demonstrated slower and weaker expiratory cough motor output compared to healthy controls. In ALS silent aspirators, blunted sensorimotor responses were observed, suggesting that sensory degradation may occur at the final or most severe stage of bulbar disease progression.
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
Journal of Medicinal Food, Ahead of Print.
Source: Journal of Medicinal Food - Category: Nutrition Authors: Source Type: research
Authors: Wada S, Nagasaki Y, Arimizu Y, Shimo M, Matsukuma Y, Okamoto M, Yoshida S, Ohashi I, Hashimoto G, Kuwashiro T, Yasaka M, Okada Y Abstract A 69-year-old man was admitted to our hospital under diagnosis of pneumonia due to SARS-CoV-2 (Day 0). He underwent endotracheal intubation from Day 3. Although his respiratory condition improved and anesthetic drugs were discontinued, no cough reflex was observed despite intubation having been performed until Day 17. His tendon reflexes were also diminished. We suspected that he had developed Guillain-Barré syndrome (GBS), and administered intravenous immunoglobu...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Myotonic dystrophy type 1 (DM1) is the most prevalent neuromuscular disease in adults and affects 1 in 8000 people worldwide [1]. It is a progressive multisystem genetic disorder caused by an unstable trinucleotide CTG repeat expansion in untranslated DNA of the DMPK gene. There is a modest positive correlation between the CTG repeat expansion, an earlier age of symptom onset, and disease severity [2]. People can be divided into four main subtypes of DM1: congenital, childhood-onset, adult-onset and late onset based on the age of onset of their symptoms with younger onset patients having increased CTG repeats and more severe disease severity.
Source: Neuromuscular Disorders - Category: Neurology Authors: Tags: Case report Source Type: research
AbstractBackgroundCough is predictive of exacerbations of chronic obstructive pulmonary disease (COPD). Little is known about cough reflex sensitivity during exacerbation of COPD and whether it is associated with exacerbation frequency. This pilot study aimed to investigate cough reflex sensitivity during and following recovery from exacerbation of COPD, and its association with the frequency of future exacerbations. In addition, the repeatability of cough reflex sensitivity in stable COPD was investigated.MethodsTwenty participants hospitalised with exacerbation of COPD underwent inhaled capsaicin challenge during exacerb...
Source: Lung - Category: Respiratory Medicine Source Type: research
In this study, the number of sensory neurons in the human JG was investigated. And, the morphology of sensory neurons in the human JG and nodose ganglion (NG) was compared. The estimated number of JG neurons was 2721.8-9301.1 (average number of sensory neurons ± S.D. = 7975.1 ± 3312.8). There was no significant difference in sizes of the neuronal cell body and nucleus within the JG (cell body, 1128.8 ± 99.7 μ m2; nucleus, 127.7 ± 20.8 μ m2) and NG (cell body, 963.8 ± 225.7 μ m2; nucleus, 123.2 ± 32.3 μ m2). These findings indicate tha...
Source: Tissue and Cell - Category: Cytology Authors: Tags: Tissue Cell Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
Respiratory failure is the primary condition requiring mechanical ventilation (MV).1 Evaluation of readiness for weaning from MV is an important procedure for reducing morbidity and mortality. Assessment processes for weaning in mechanically ventilated patients can be divided into clinical assessment and physical assessment. Clinical assessments include adequacy of cough reflex, reduction of sputum production and lack of symptoms requiring intubation. Physical assessments are stable vital signs, adequate oxygenation, good lung mechanics, and rapid shallow breathing index (RSBI) less than 105/liter/minute.
Source: Heart and Lung - Category: Intensive Care Authors: Source Type: research
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