Antitussive therapy: A role for levodropropizine

Publication date: Available online 11 March 2019Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Surinder Birring, Francesco de Blasio, Peter Dicpinigaitis, Giovanni Fontana, Luigi Lanata, Clive Page, Federico Saibene, Alessandro ZanasiAbstractCough is a protective reflex that serves to clear the airways of excessive secretions and foreign matter and which sometimes becomes excessive, and troublesome to patients. Cough is one of the most common reasons why individuals seek medical attention. A range of drugs have been developed in the past with antitussive activity and different mechanisms of action, but there are still very few safe and effective treatments available. The poor tolerability of most available antitussives is closely related to their action on the central nervous system (CNS). An international group of experts specialized in cough met to discuss the need to identify an effective antitussive treatment with a good tolerability profile.The aim of this expert review is to increase the knowledge about the cough mechanism and the activity of levodropropizine, a peripherally acting antitussive drug.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research