Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis

ConclusionOur findings indicate that T cells that recognize citrullinated aggrecan are present in patients with RA and correlate with antibodies that target this same antigen. Consequently, aggrecan ‐specific T cells and antibodies are potentially relevant markers that could be used to monitor patients with RA or at‐risk subjects.

Source: Arthritis and Rheumatology - March 7, 2019 Category: Rheumatology Authors: Cliff Rims, Hannes Uchtenhagen, Mariana J. Kaplan, Carmelo Carmona ‐Rivera, Philip Carlucci, Katalin Mikecz, Adrienn Markovics, Jeffrey Carlin, Jane H. Buckner, Eddie A. James Tags: Original Article Source Type: research