Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer.

Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer. Cancer Invest. 2019 Mar 05;:1-5 Authors: Nichols RC, Morris CG, Bryant C, Hoppe BS, Henderson RH, Mendenhall WM, Li Z, Costa JA, Williams CR, Mendenhall NP Abstract Studies demonstrate a decline of ∼10% in serum testosterone (ST) level after X-ray radiotherapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60+ months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0-974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0-1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays. PMID: 30836776 [PubMed - as supplied by publisher]
Source: Cancer Investigation - Category: Cancer & Oncology Tags: Cancer Invest Source Type: research